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Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
689
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

683
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
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Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
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Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
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How and when to use clozapine.

J M Rubio1,2,3, J M Kane1,2,3

  • 1Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Glen Oaks, NY, USA.

Acta Psychiatrica Scandinavica
|October 12, 2019
PubMed
Summary
This summary is machine-generated.

Clozapine is an effective treatment for schizophrenia but is underused. This review provides practical recommendations to overcome barriers and improve clozapine utilization in clinical practice.

Keywords:
psychosissevere mental illnesstreatment-resistant schizophrenia

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Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is the sole approved medication for treatment-resistant schizophrenia.
  • Despite its efficacy, clozapine remains significantly underutilized in clinical practice.

Purpose of the Study:

  • To provide evidence-based recommendations for clozapine use.
  • To address practical barriers hindering clozapine prescription.

Main Methods:

  • Narrative review of existing literature.
  • Identification of obstacles to clozapine utilization.

Main Results:

  • Evidence confirms clozapine's efficacy in reducing schizophrenia morbidity and mortality.
  • Key barriers include prescriber inexperience and perceived treatment burden.
  • Strategies for overcoming barriers include systematic screening, consultation resources, professional networking, and patient communication.

Conclusions:

  • A significant gap exists between clozapine's proven efficacy and its clinical utilization.
  • Updating routine clinical practices can help surmount existing barriers to clozapine prescription.