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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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CTLA-4 (CD152): A versatile receptor for immune-based therapy

Holger Lingel1, Monika C Brunner-Weinzierl1

  • 1Department of Experimental Pediatrics, University Hospital, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.

Seminars in Immunology
|October 13, 2019
PubMed

Insights

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a key regulator of immune responses and a target for cancer immunotherapy. Further understanding CTLA-4 biology is crucial for improving existing cancer treatments.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Immunotherapy

Background:

  • Coreceptor-based immunotherapy is a rapidly advancing cancer treatment strategy.
  • Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a critical attenuator of adaptive immune responses.
  • CTLA-4 plays a significant role in regulating immune cell functions, offering therapeutic intervention possibilities.

Purpose of the Study:

  • To review the diverse functions of CTLA-4.
  • To examine CTLA-4-based immunotherapies.
  • To discuss challenges and potential improvements for current CTLA-4-targeted approaches.

Main Methods:

  • Literature review of CTLA-4 functions.
  • Analysis of clinical data for CTLA-4-based immunotherapies.
  • Discussion of unresolved aspects of CTLA-4 biology.

Main Results:

  • CTLA-4 is a prominent and extensively studied molecule in cancer immunotherapy.
  • CTLA-4 is successfully utilized in clinical treatments.
  • Despite clinical success, the complete biology of CTLA-4 remains incompletely understood.

Conclusions:

  • CTLA-4-based immunotherapies represent a promising area in cancer treatment.
  • Further research into CTLA-4 functions is needed to optimize therapeutic strategies.
  • Addressing the gaps in understanding CTLA-4 biology will enhance its clinical application.
Keywords:
AbataceptCTLA-4Cancer immunotherapyImmune checkpointIpilimumab

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