Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

751
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
751
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

1.9K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
1.9K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

953
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
953

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A context-free model of savings in motor learning.

eLife·2026
Same author

Evolutionarily conserved neural dynamics across mice, monkeys, and humans.

bioRxiv : the preprint server for biology·2026
Same author

Sensory expectations shape neural population dynamics in motor circuits.

Nature·2025
Same author

A Crowdsourced Megastudy of 12 Digital Single-Session Interventions for Depression in American Adults.

Research square·2025
Same author

The impact of adverse childhood experiences on age of diabetes diagnosis and associations with race and ethnicity.

Journal of osteopathic medicine·2025
Same author

Quality of Life Among Adolescents and Young Adults with Melanoma: A Systematic Review.

Journal of adolescent and young adult oncology·2025
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

22.0K

Domain-Specific Working Memory, But Not Dopamine-Related Genetic Variability, Shapes Reward-Based Motor Learning.

Peter Holland1, Olivier Codol2, Elizabeth Oxley2

  • 1School of Psychology and Centre for Human Brain Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom P.J.Holland@bham.ac.uk.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 13, 2019
PubMed
Summary
This summary is machine-generated.

Working memory capacity, specifically spatial working memory (SWM), is key for success in reward-based motor learning. This study found SWM, not dopamine genetics, significantly predicts performance in motor tasks utilizing rewarding feedback.

Keywords:
geneticsmotor learningreachingrewardworking memory

More Related Videos

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.4K
Author Spotlight: Unveiling Neural Mechanisms Through Automated Evaluation of Motor Learning and Myelin Plasticity Studies Using the Erasmus Ladder
08:51

Author Spotlight: Unveiling Neural Mechanisms Through Automated Evaluation of Motor Learning and Myelin Plasticity Studies Using the Erasmus Ladder

Published on: December 15, 2023

1.9K

Related Experiment Videos

Last Updated: Jan 5, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

22.0K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.4K
Author Spotlight: Unveiling Neural Mechanisms Through Automated Evaluation of Motor Learning and Myelin Plasticity Studies Using the Erasmus Ladder
08:51

Author Spotlight: Unveiling Neural Mechanisms Through Automated Evaluation of Motor Learning and Myelin Plasticity Studies Using the Erasmus Ladder

Published on: December 15, 2023

1.9K

Area of Science:

  • Neuroscience
  • Motor Learning
  • Cognitive Psychology

Background:

  • Rewarding feedback enhances motor learning retention but causes significant interindividual variability.
  • Understanding factors influencing this variability is crucial for optimizing rehabilitation strategies.
  • Previous research highlights the need to identify predictors of success in reward-based motor learning.

Purpose of the Study:

  • To investigate the association between working memory capacity (spatial, verbal, and rotation) and genetic profiles related to dopamine with performance in reward-based motor tasks.
  • To identify key factors contributing to individual differences in reward-based motor learning.
  • To explore the role of spatial working memory (SWM) and rotation working memory (RWM) in motor task success.

Main Methods:

  • A large cohort (n=241) of both sexes performed two reward-based motor tasks with binary feedback.
  • Participants' spatial (SWM), verbal, and rotation (RWM) working memory capacities were assessed.
  • Dopamine-related genetic profiles were analyzed for associations with task performance.

Main Results:

  • Higher SWM was significantly associated with greater success and improved reproduction of motor actions.
  • Higher RWM predicted the use of explicit strategies during motor adjustments.
  • No significant association was found between dopamine-related genotypes and motor task performance.

Conclusions:

  • Domain-specific working memory capacity, particularly SWM, is a pivotal predictor of individual success in reward-based motor learning.
  • The findings highlight a dissociable role for SWM and RWM in different aspects of reward-based motor learning.
  • Contrary to expectations, dopamine genetics did not influence performance, suggesting working memory is a primary determinant.