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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

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Published on: November 25, 2015

A chemically fueled non-enzymatic bistable network.

Indrajit Maity^1,2, Nathaniel Wagner¹, Rakesh Mukherjee^1,3

¹Department of Chemistry, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.

Nature Communications

|October 13, 2019

Summary

This summary is machine-generated.

Researchers created synthetic molecular networks that mimic life-like functions. These thiodepsipeptide networks display bistability, a key step towards understanding complex dynamic behaviors in systems chemistry.

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Area of Science:

Systems Chemistry
Chemical Networks
Biomimetic Systems

Background:

Mimicking life-like functions with synthetic molecular networks is a grand challenge.
Systems far from chemical equilibrium exhibit complex dynamics like multi-stability, oscillations, and chaos.

Purpose of the Study:

To develop non-enzymatic molecular networks capable of mimicking life-like functions.
To investigate bistable behavior in synthetic systems driven by reversible replication.

Main Methods:

Utilized thiodepsipeptide-based molecular networks.
Propelled networks using reversible replication processes out of chemical equilibrium.
Quantitatively analyzed bistable behavior and phase transitions.

Main Results:

Demonstrated bistability in non-enzymatic thiodepsipeptide networks.
Observed a phase transition from equilibration to bistability.
Bistability was contingent on continuous fueling by a reducing agent and specific parameter ranges.

Conclusions:

Thiodepsipeptide networks can exhibit biomimetic bistability.
Continuous fueling is crucial for maintaining systems far from equilibrium.
These findings pave the way for studying more complex functions like information transfer and signaling.