Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen presenting cells and bone allotransplantation.

A A Czitrom, T Axelrod, B Fernandes

    Clinical Orthopaedics and Related Research
    |July 1, 1985
    PubMed
    Summary

    Antigen-presenting cells in bone marrow, identified as granulocytes, can trigger immune responses in bone allotransplantation. Removing these cells from grafts may reduce transplant rejection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gellan gum/honey-based gels and hydrogels for cutaneous wound management.

    International journal of pharmaceutics·2026
    Same author

    Improving non-small-cell lung cancer survival through molecular characterization: Perspective of a multidisciplinary expert panel.

    Pulmonology·2023
    Same author

    Primary brain necrotizing granulomas caused by Curvularia spicifera.

    Infectious diseases now·2022
    Same author

    The golden bronchus.

    Respiratory medicine and research·2021
    Same author

    Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.

    Neuropathology and applied neurobiology·2020
    Same author

    Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor.

    Dermatology online journal·2019

    Area of Science:

    • Immunology
    • Transplantation Biology
    • Cell Biology

    Background:

    • Bone marrow contains antigen-presenting cells (APCs) crucial for immune responses.
    • These APCs are distinct from T and B lymphocytes.
    • Evidence indicates these cells originate from the granulocyte lineage.

    Purpose of the Study:

    • To investigate the role of bone marrow APCs in bone allotransplantation.
    • To determine if these APCs initiate immunologic reactions.
    • To assess the impact of APC removal on transplant outcomes.

    Main Methods:

    • Identification and characterization of APCs within bone marrow.
    • In vitro studies to assess the immunogenic potential of these cells.
    • Experimental bone allotransplantation models with and without APC depletion.

    Main Results:

    • Bone marrow APCs were confirmed to be non-T, non-B lymphocytes.
    • These APCs were identified as granulocytes.
    • In vitro studies demonstrated their capacity to initiate immune reactions.
    • Removal of these cells from bone allografts reduced the immunologic response.

    Conclusions:

    • Bone marrow-derived granulocytes act as potent antigen-presenting cells.
    • These cells play a significant role in the immune response to bone allotransplants.
    • Depleting these cells from bone allografts is a viable strategy to mitigate immune rejection.

    Related Experiment Videos