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Evaluation of Clinical, Laboratory and Treatment Modalities in C3 Glomerulopathy: Single Center Experience

H Hasan Yeter1, Erdem Sütiçen2, Berfu Korucu1

  • 1Nephrology fellowship,Department of Nephrology, Gazi University, Ankara, Turkey.

Prilozi (Makedonska Akademija Na Naukite I Umetnostite. Oddelenie Za Medicinski Nauki)
|October 13, 2019
PubMed

Insights

C3 glomerulopathy (C3GP) treatment with mycophenolate mofetil (MMF) or without showed similar efficacy. High creatinine levels and need for renal replacement therapy predict end-stage renal disease (ESRD) in C3GP patients.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • C3 glomerulopathy (C3GP) is a rare nephropathy potentially leading to end-stage renal disease (ESRD).
  • Prognostic factors and optimal treatments for C3GP remain incompletely understood.
  • Histopathologic features require further definition.

Purpose of the Study:

  • To investigate demographic, histological, treatment, and outcome data in C3GP patients.
  • To identify predictors of renal survival in C3GP.

Main Methods:

  • Retrospective observational study of C3GP patients (2013-2017).
  • Inclusion criteria: kidney biopsies fulfilling C3GP criteria.
  • Analysis of treatment modalities (MMF-based vs. non-MMF-based) and outcomes.

Main Results:

  • Twenty-four C3GP patients (50% male, mean age 43) were analyzed.
  • 21% of patients progressed to ESRD.
  • Histological findings (crescent formation, glomerulosclerosis, tubular atrophy) did not differ significantly between ESRD and non-ESRD groups.
  • No significant difference in eGFR preservation or complete remission rates between MMF-based and non-MMF-based treatments.
  • Serum creatinine >2.3 mg/dL and need for renal replacement therapy (RRT) at admission correlated with poorer renal survival.

Conclusions:

  • MMF-based and non-MMF-based treatments demonstrate comparable efficacy in C3GP.
  • Elevated serum creatinine (>2.3 mg/dL) and the requirement for RRT at diagnosis are strong predictors of ESRD in C3GP.
Abstract

Keywords:
C3 glomerulopathyeculizumabend stage renal diseasemycophenolate mofetil

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