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Updated: Jan 5, 2026
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Coronary Artery Disease in Patients with Ischemic Stroke and TIA
Rohit Bhatia1, Gautam Sharma2, Chetan Patel3
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Insights
Coronary artery disease (CAD) is common in ischemic stroke (IS) patients. Further research is needed to identify individuals who may benefit from subclinical CAD screening after a stroke.
Area of Science:
- Cardiology
- Neurology
- Nuclear Medicine
Background:
- Ischemic stroke (IS) and coronary artery disease (CAD) share risk factors.
- One condition may indicate the presence of the other.
Purpose of the Study:
- To determine the prevalence of symptomatic and asymptomatic CAD in IS patients.
- To investigate the association between CAD and large artery cerebrovascular disease (LAD) in IS patients.
Main Methods:
- Consecutive IS and Transient Ischemic Attack (TIA) patients were enrolled.
- Myocardial perfusion SPECT scans (Tc99m MIBI) were used to detect myocardial ischemia in 259 patients.
- SPECT-CT imaging was performed for detailed analysis.
Main Results:
- Overall CAD prevalence was 17.67% (53/300 patients).
- Diabetes was an independent predictor of CAD (OR 1.98).
- No significant association was found between LAD and CAD, though a trend suggested higher LAD in known CAD patients.
Conclusions:
- CAD is prevalent in patients with ischemic stroke.
- No definitive link was established between CAD and intracranial or extracranial LAD.
- Population-based tools are needed to guide subclinical CAD screening in stroke patients.
Background And Objectives:
Ischemic stroke (IS) and coronary artery disease (CAD) share common risk factors and one may be the harbinger of the other. We aimed to study prevalence of symptomatic and asymptomatic CAD in a cohort of consecutive patients with IS and assess its relationship with intracranial and extracranial large artery cerebrovascular disease (LAD).
Methods:
All consecutive eligible IS and Transient Ischemic Attack (TIA) patients were recruited into the study. Both clinically suspected and asymptomatic patients (N = 259) underwent myocardial Stress-rest Gated Technetium-99m (Tc99m) MIBI Myocardial Perfusion SPECT scan performed on a dual head SPECT-CT to estimate evidence of myocardial ischemia.
Results:
Three hundred patients completed the study. Forty one patients were previously diagnosed cases of definitive CAD. Twelve patients were clinically suspected to have CAD and 247 patients were asymptomatic. Among these, 12 patients (4.81%) had a positive SPECT. The overall prevalence of CAD was 17.67% (n = 53). Presence of diabetes was an independent predictor of CAD (OR 1.98, 95% CI 1.07-3.67. P .02). No significant association was found between the presence of LAD and CAD in all subgroup comparisons. However, there was a suggestion of higher LAD among patients with known CAD compared with others.
Conclusions:
CAD is prevalent in patients with ischemic stroke. No definitive relationship was found between CAD and intracranial or extracranial LAD. Population based stratification tools are needed to further assess the need to detect subclinical CAD in patients with stroke.
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