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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Gastritis-I: Introduction and Types01:27

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Jan 5, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Autoimmune polyglandular diseases.

George J Kahaly1, Lara Frommer1

  • 1Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany.

Best Practice & Research. Clinical Endocrinology & Metabolism
|October 14, 2019
PubMed
Summary

Autoimmune polyglandular diseases (APD) involve multiple endocrine failures. Early detection and regular screening of at-risk individuals and families are crucial for better outcomes and managing this condition.

Keywords:
autoimmune polyglandular diseasefamilial clusteringmanagementpathophysiologypsychosocial morbidity

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Area of Science:

  • Endocrinology
  • Genetics
  • Immunology

Background:

  • Autoimmune polyglandular diseases (APD) are characterized by two or more autoimmune-induced endocrine failures.
  • APD is associated with significant morbidity and mortality, necessitating early diagnosis.
  • Subclinical endocrinopathies often precede clinical manifestation, highlighting the need for proactive screening.

Purpose of the Study:

  • To emphasize the importance of early detection of APD.
  • To advocate for regular screening of at-risk individuals and families.
  • To highlight the need for long-term follow-up and multidisciplinary management.

Main Methods:

  • Review of existing literature on APD diagnosis and management.
  • Analysis of the clinical course and familial clustering of APD.
  • Assessment of the impact of APD on quality of life and psychosocial status.

Main Results:

  • Early detection of APD leads to fewer complications, effective therapy, and improved prognosis.
  • Regular screening of at-risk patients and first-degree relatives is essential for identifying subclinical endocrinopathies.
  • Familial clustering is common in APD, indicating a genetic predisposition.

Conclusions:

  • Long-term follow-up and regular screening are critical for managing APD.
  • Multidisciplinary management in specialized centers is recommended for affected families.
  • Addressing the psychosocial needs of APD patients and their relatives is important.