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Design-augmented (DA) biologics: BMP chimeras for bone and cartilage regeneration

P C Gray1, S Choe2

  • 1Qualcomm Institute, University of California San Diego, Atkinson Hall - Fifth Floor, 9500 Gilman Drive #0436, La Jolla, CA 92093-0436, USA.

Osteoarthritis and Cartilage
|October 14, 2019
PubMed
Summary

No abstract available in PubMed .

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...