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Related Experiment Video

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Smartphone controlled interactive portable device for theranostics in vitro.

Sunil Kumar Sailapu1, Deepanjalee Dutta1, Anitha T Simon1

  • 1Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781 039, Assam, India.

Biosensors & Bioelectronics
|October 14, 2019
PubMed
Summary
This summary is machine-generated.

A novel smartphone-controlled device enables in vitro photodynamic therapy (PDT) and diagnostics using silver nanorods (Ag NRs). This theranostic platform effectively eliminates cancer cells, demonstrating potential for advanced cancer treatment assessment.

Keywords:
Colorimetric assaysDiagnosisLEDPhotodynamic therapyPortable deviceSmartphoneTheranostics

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Photodynamic Therapy

Background:

  • Photodynamic therapy (PDT) offers a targeted approach for cancer treatment.
  • Developing integrated platforms for both therapy and diagnostics is crucial for effective treatment assessment.
  • Silver nanorods (Ag NRs) show promise as photosensitizers in PDT.

Purpose of the Study:

  • To develop a smartphone-controlled theranostic device for in vitro PDT and diagnostic assays.
  • To evaluate the efficacy of Ag NRs as photosensitizers in PDT across different cell lines.
  • To assess the therapeutic success of PDT combined with doxorubicin (Dox) using standard assays.

Main Methods:

  • Development of a portable, smartphone-controlled theranostic device.
  • Utilizing silver nanorods (Ag NRs) as photosensitizers with low-intensity LED irradiation (632 nm).
  • Conducting MTT and lactate dehydrogenase (LDH) assays to evaluate cell viability and therapeutic outcomes.

Main Results:

  • Ag NRs demonstrated effective PDT in three cell lines, particularly HeLa cancer cells and multicellular tumor spheroids.
  • Combined PDT with doxorubicin (Dox) showed significant cancer cell killing at a minimum Ag dose of 2.5 μg/mL.
  • MTT and LDH assays confirmed the therapeutic success of the delivered PDT.

Conclusions:

  • The developed theranostic device offers a portable and versatile platform for in vitro PDT and treatment assessment.
  • Smartphone control and wireless operation enhance usability in complex settings.
  • Ag NR-mediated PDT, especially when combined with Dox, presents a potent strategy for cancer therapy.