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Sphk1 promotes ulcerative colitis via activating JAK2/STAT3 signaling pathway

Jiawen Liu1, Bo Jiang2

  • 1Department of Gastroenterology, Beijing TsingHua Changgung Hospital, No. 168, LiTang Road, Beijing, 102218, China.

Human Cell
|October 14, 2019
PubMed
Summary

Sphingosine kinase 1 (SphK1) promotes ulcerative colitis (UC) progression by increasing cell proliferation and pro-inflammatory cytokine secretion. Inhibiting SphK1 may offer a new therapeutic strategy for treating UC.

Keywords:
JAK2/STAT3NF-κBSphk1Ulcerative colitis

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