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[Evaluation of neurovascular function in mouse cortex using multispectral optical imaging after ischemic stroke].

Y Q Zhu1, M Y Zhao, X C Gu

  • 1Medical School of Southeast University, Jiangsu Key Lab of Molecule Imaging and Functional Imaging, Nanjing 210009, China.

Zhonghua Yi Xue Za Zhi
|October 15, 2019
PubMed
Summary

Optical imaging of neuron excitability and blood oxygen in mice reveals significant correlations with ischemic stroke severity. These neurovascular signals can effectively track stroke progression and neurological deficits.

Keywords:
Blood vesselsStrokeTomography, optical

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cerebrovascular Research

Background:

  • Ischemic stroke significantly impacts neurovascular function.
  • Accurate monitoring of stroke progression and its effects on brain tissue is crucial for effective treatment.
  • Current methods for assessing stroke severity have limitations in real-time evaluation.

Purpose of the Study:

  • To measure neuron excitability and blood oxygen signals in the mouse cortex post-ischemic stroke.
  • To investigate the relationship between neurovascular function changes and the extent of cerebral infarction.
  • To evaluate the utility of optical imaging for monitoring stroke progression.

Main Methods:

  • Photochemical injury model to induce embolic stroke in C57BL/6 mice.
  • Multispectral optical imaging to acquire neuron excitability, total hemoglobin, and deoxygenated hemoglobin signals.
  • TTC staining for cerebral infarction size, ELISA for TNF-α, and modified neurological severity score (mNSS) for neurological deficits.

Main Results:

  • Neuron excitability, total hemoglobin, and deoxygenated hemoglobin signals showed dynamic changes post-stroke.
  • Neural signals correlated significantly with cerebral infarction size, plasma TNF-α levels, and mNSS.
  • Total hemoglobin concentration also correlated with cerebral infarction size.

Conclusions:

  • Optical imaging of neuron excitability and blood oxygen provides valuable insights into neurovascular function changes after ischemic stroke.
  • These optical signals can serve as reliable indicators for evaluating stroke progression and severity.
  • The findings support the use of multispectral optical imaging for real-time stroke monitoring.