Related Experiment Video

Updated: Jan 5, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.0K

The Emerging Role of Major Regulatory RNAs in Cancer Control

Xiaofeng Dai1, Aman Chandra Kaushik1,2, Jianying Zhang3

  • 1Wuxi School of Medicine, Jiangnan University, Wuxi, China.

Frontiers in Oncology
|October 15, 2019
PubMed

Insights

Regulatory RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are crucial in cancer. Understanding their roles offers new diagnostic, prognostic, and therapeutic strategies for improved cancer management.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • RNA interactions are linked to disease etiology and phenotypes.
  • Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are key regulatory molecules implicated in human malignancies.
  • Deregulation of these non-coding RNAs (ncRNAs) contributes to cancer initiation and progression.

Purpose of the Study:

  • To review the critical roles of lncRNAs and miRNAs in tumorigenesis.
  • To scrutinize their potential as diagnostic/prognostic biomarkers and therapeutic targets.
  • To outline opportunities and challenges in translating ncRNA research to clinical practice.

Main Methods:

  • Literature review and synthesis of current research on lncRNAs and miRNAs in cancer.
  • Analysis of the functional roles of ncRNAs in tumorigenesis.
  • Evaluation of clinical applications and translational challenges.

Main Results:

  • lncRNAs and miRNAs play significant roles in cancer development and progression.
  • These ncRNAs show promise as biomarkers for cancer diagnosis and prognosis.
  • ncRNAs represent potential therapeutic targets for cancer treatment.

Conclusions:

  • Regulatory RNAs offer novel avenues for cancer management.
  • Further research is needed to overcome challenges in translating ncRNA knowledge to the bedside.
  • ncRNAs have the potential to complement existing clinical practices in oncology.
Keywords:
biomarkercancerlong non-coding RNAmicroRNAtherapeutics

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.8K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K