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Maternal obesity and gestational diabetes decrease Metrnl concentrations in cord plasma.

Martha Lappas1

  • 1Department of Obstetrics and Gynaecology, Obstetrics, Nutrition and Endocrinology Group, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 15, 2019
PubMed
Summary
This summary is machine-generated.

Maternal obesity and gestational diabetes mellitus (GDM) are linked to lower Metrnl levels in cord plasma, potentially impacting fetal growth and future metabolic health.

Keywords:
Cord plasmaGDMmaternal obesitymetrnlpregnancy

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Perinatal Medicine

Background:

  • Metrnl is an adipokine with potential roles in metabolic regulation.
  • Maternal metabolic conditions like obesity and gestational diabetes mellitus (GDM) can influence fetal development.
  • Understanding Metrnl's role in pregnancy is crucial for assessing fetal metabolic programming.

Purpose of the Study:

  • To investigate the impact of maternal obesity and GDM on Metrnl levels in maternal and cord plasma.
  • To explore correlations between Metrnl levels and anthropometric/laboratory parameters.

Main Methods:

  • Maternal and cord plasma Metrnl levels were measured using enzyme-linked immunoassay.
  • Participants included women with normal glucose tolerance (NGT) and GDM (diet or insulin-controlled), stratified by obesity status.
  • Correlations with gestational weight gain (GWG) and glucose levels were assessed.

Main Results:

  • Maternal plasma Metrnl was unaffected by obesity or GDM.
  • Cord plasma Metrnl was significantly lower in obese NGT women and non-obese GDM women compared to non-obese NGT controls.
  • Positive correlations were found between maternal and cord Metrnl, and between cord Metrnl and GWG/glucose levels.

Conclusions:

  • Preexisting maternal obesity and GDM are associated with reduced cord plasma Metrnl levels at term.
  • Lowered cord Metrnl may influence fetal growth and predispose to later-life metabolic disorders.