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Change Is the Only Constant: How to Adopt the New Trends in Sepsis Modeling?

Marcin F Osuchowski1, Matthew R Rosengart

  • 1Division of Intensive Care Medicine Ludwig Boltzmann Institute for Experimental and ClinicalTraumatology in the AUVA Research Center, Vienna, Austria Department of Surgery; and Department of Critical Care Medicine, Institute of Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Critical Care Medicine
|October 15, 2019
PubMed
Abstract

No abstract available in PubMed .

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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