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Published on: December 15, 2017
Evaluation of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging for Detection of Bowel
Hai-Jing Yang1, Yu-Ling Xi2, Xue-Ni Guan2
1From the Department of Phase I Clinical Research Center, Huashan Hospital, Fudan University.
Objectives:
This study aimed to evaluate the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting bowel inflammation in patients with Crohn disease (CD).
Methods:
Sixteen patients who underwent intravoxel incoherent motion DW-MRI for CD and colonoscopy were recruited. Seventy-nine bowel segments were selected, and their mean D, D*, f, and apparent diffusion coefficient (ADC) values were measured. The receiver operating characteristic curve was performed to distinguish inflamed from normal bowel.
Results:
The mean D, D*, f, and ADC values of inflamed bowel were significantly lower than those of normal bowel (P < 0.05). The area under the receiver operating characteristic curve for f (0.906) and ADC values (0.924) was greater than that for D (0.709) or D* values (0.686) for differentiating inflamed bowel from normal bowel (P < 0.05).
Conclusions:
Intravoxel incoherent motion DW-MRI is a feasible technique for detecting inflammation in CD patients. The ADC and f values have more potential than the D and D* values.
Insights
Intravoxel incoherent motion diffusion-weighted MRI (DW-MRI) effectively detects bowel inflammation in Crohn disease (CD) patients. Apparent diffusion coefficient (ADC) and f values show the most promise for identifying inflamed bowel segments.
Area of Science:
- Radiology
- Gastroenterology
- Medical Imaging
Background:
- Crohn disease (CD) is a chronic inflammatory bowel disease.
- Accurate detection of bowel inflammation is crucial for CD management.
- Current diagnostic methods may have limitations.
Purpose of the Study:
- To assess the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting bowel inflammation in CD patients.
- To compare the diagnostic performance of different DW-MRI parameters.
Main Methods:
- Sixteen CD patients underwent intravoxel incoherent motion DW-MRI and colonoscopy.
- Seventy-nine bowel segments were analyzed for mean D, D*, f, and apparent diffusion coefficient (ADC) values.
- Receiver operating characteristic (ROC) curve analysis was used to differentiate inflamed from normal bowel.
Main Results:
- Inflamed bowel segments showed significantly lower mean D, D*, f, and ADC values compared to normal segments (P < 0.05).
- The area under the ROC curve was highest for f (0.906) and ADC (0.924), indicating superior performance in differentiating inflamed from normal bowel.
- D and D* values demonstrated lower diagnostic accuracy (0.709 and 0.686, respectively).
Conclusions:
- Intravoxel incoherent motion DW-MRI is a feasible and promising technique for detecting bowel inflammation in CD.
- ADC and f values are more effective than D and D* values for distinguishing inflamed from normal bowel in CD patients.
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