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Related Concept Videos

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Related Experiment Video

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High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
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Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.

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Short-term interval training reduced endothelial extracellular vesicles (EV) in adults with prediabetes. Increased fitness correlated with decreased EV, but higher sugar intake may counteract exercise benefits.

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Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Extracellular vesicles (EV) are implicated in type 2 diabetes and cardiovascular disease (CVD) risk.
  • Physical activity and diet are known disease risk reducers.
  • No studies have compared interval (INT) versus continuous (CONT) training's effect on EV in prediabetes.

Purpose of the Study:

  • To test if short-term INT exercise reduces EV more than CONT exercise in adults with prediabetes.
  • To examine the impact of exercise intensity on EV subtypes.
  • To investigate the relationship between changes in cardiorespiratory fitness, diet, and EV levels.

Main Methods:

  • Eighteen obese adults with prediabetes were randomized to 12 sessions of INT or CONT training over 13 days.
  • Cardiorespiratory fitness (V˙O2peak), weight, and arterial stiffness were assessed.
  • EV subtypes (total, platelet, endothelial, leukocyte) were analyzed via imaging flow cytometry pre- and post-intervention.

Main Results:

  • INT exercise significantly increased V˙O2peak compared to CONT training.
  • INT exercise decreased endothelial-derived EV (Annexin V- CD105) compared to CONT, but this effect was lost after accounting for sugar intake.
  • Increased sugar intake was linked to elevated EV, while increased V˙O2peak correlated with decreased EV.

Conclusions:

  • Interval exercise training can decrease endothelial-derived EV in individuals with prediabetes.
  • While increased sugar consumption may influence EV levels post-exercise, improved cardiorespiratory fitness is associated with reduced EV counts.