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Intestinal lymphoid tissue changes in the cortisone-treated Wistar rat
Morphologie Et Embryologie
|April 1, 1985
Summary
Cortisone administration initially caused intestinal lymphoid tissue hyperplasia and bone marrow hypercellularity in Wistar rats. Following a 6-week recovery, cellular depletion was observed alongside normalized bone marrow and lymph node parenchyma.
Area of Science:
- Endocrinology
- Immunology
- Histology
Background:
- Previous research investigated lymphoid tissue responses under varied conditions.
- Endocrine imbalance is known to affect immune system components.
Purpose of the Study:
- To examine the morphological changes in intestinal lymphoid tissue of male Wistar rats following cortisone administration.
- To understand the recovery process of lymphoid tissues after endocrine disruption.
Main Methods:
- Male Wistar rats were administered cortisone.
- Intestinal lymphoid tissue, lymph nodes, and bone marrow were analyzed morphologically at 7 days post-administration and after a 6-week recovery interval.
Main Results:
- Cortisone induced intestinal lymphoid tissue hyperplasia, lymph node parenchyma depletion, and bone marrow hypercellularity at 7 days.
- After 6 weeks, lymphoid tissue showed cellular depletion, with restored lymph node parenchyma and normocellular bone marrow.
Conclusions:
- Cortisone administration causes significant, time-dependent alterations in lymphoid tissue morphology.
- The lymphoid system exhibits a capacity for recovery following short-term endocrine imbalance induced by cortisone.