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Author Spotlight: Expanding the Scope of Multiplex Immunoassays for Lyme Borreliosis Diagnostics and Pathogen Research
Published on: July 14, 2023
[Meningitis due to infection with Borrelia hispanica]
Jennie Heida1,2, Andreas van Arkel3, Jaco J Verweij3
1Elisabeth-TweeSteden Ziekenhuis, afd. Neurologie, Tilburg.
Abstract:
BACKGROUND Tick-borne relapsing fever is a disease that is caused by infection with a Borrelia bacterium, and is transmitted by ticks. This infectious disease is characterised by relapsing episodes of high fever, often accompanied by aspecific symptoms. CASE DESCRIPTION We describe the history of a 20-year-old woman who developed recurrent episodes of fever with headache and vomiting after a holiday in Morocco. Additional examination showed pleiocytosis in the cerebrospinal fluid, which was initially suggestive of viral meningitis. However, Borrelia spp. were isolated from a 16S-rRNA-PCR-test which led to the diagnosis 'tick-borne relapsing fever'. The patient was treated with intravenous ceftriaxone for two weeks, after which time her symptoms gradually improved. CONCLUSION Prompt antibiotic treatment of tick-borne relapsing fever can prevent a serious course of the disease. For this reason, in patients with recurrent episodes of fever, it is important to consider this diagnosis if they have recently made a trip to Africa, America or the Middle East.
Insights
Tick-borne relapsing fever, caused by Borrelia bacteria transmitted by ticks, presents with recurrent fevers. Early antibiotic treatment, like ceftriaxone, is crucial for recovery and preventing severe illness.
Area of Science:
- Infectious Diseases
- Bacteriology
- Neurology
Background:
- Tick-borne relapsing fever (TBRF) is an infection caused by Borrelia bacteria transmitted through tick bites.
- The disease is characterized by recurring high fever episodes and non-specific symptoms.
Observation:
- A 20-year-old woman presented with recurrent fever, headache, and vomiting after traveling to Morocco.
- Cerebrospinal fluid analysis revealed pleocytosis, initially suggesting viral meningitis.
- Borrelia species were identified via 16S-rRNA PCR, confirming TBRF.
Findings:
- The patient received a two-week course of intravenous ceftriaxone.
- Symptoms gradually improved following antibiotic treatment.
Implications:
- Prompt diagnosis and antibiotic therapy are essential for managing TBRF and preventing severe outcomes.
- Clinicians should consider TBRF in patients with recurrent fevers, especially after travel to endemic regions in Africa, America, or the Middle East.
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