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Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

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Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
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Healthcare Associated Infections II: Preventive Measures01:22

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Comparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).

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Related Experiment Video

Updated: Jan 5, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
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Use of impregnated catheters to decrease colonization rates in neonates - A randomized controlled pilot trial.

M Klemme1, A Staffler2, N De Maio1

  • 1Division of Neonatology, Dr. v. Hauner Children's Hospital and Perinatal Center Munich - Grosshadern, LMU Munich, Germany.

Journal of Neonatal-Perinatal Medicine
|October 15, 2019
PubMed
Summary
This summary is machine-generated.

Antibiotic and antimycotic impregnated peripherally inserted central catheters (PICC) tended to reduce colonization in neonates, but the difference was not statistically significant. Lower gestational age and male sex were identified as risk factors for catheter colonization.

Keywords:
Preterm infantantibiotic and antimycotic impregnated catheterscatheter related infectioncentral venous linecolonization

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Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
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Area of Science:

  • Neonatal intensive care
  • Infectious diseases
  • Medical device technology

Background:

  • Nosocomial infections pose significant risks to preterm infants, increasing mortality and morbidity.
  • Central venous catheter colonization is a primary risk factor for these infections.
  • While impregnated catheters show promise in adults and older children, their efficacy in neonates remains under investigation.

Purpose of the Study:

  • To evaluate the impact of antibiotic and antimycotic impregnated peripherally inserted central catheters (PICC) on catheter colonization rates in preterm and sick term infants.
  • To assess the incidence of catheter-associated infections with standard versus impregnated PICC-lines.

Main Methods:

  • A randomized controlled trial involving neonates assigned to either standard (S-PICC) or impregnated (IP-PICC) PICC-lines.
  • Catheter colonization was assessed using roll-out cultures, with >15 colony-forming-units/ml defining colonization.
  • Outcomes included colonization rates, catheter-related local infections (CRI), and catheter-related systemic infections (CR-SI).

Main Results:

  • Catheter colonization rates were lower in the IP-PICC group (5.6%) compared to the S-PICC group (12.1%), though this difference was not statistically significant (p=0.42).
  • No significant differences were observed in CRI (2.9% vs. 6.1%; p=0.60) or CR-SI (0% vs. 3.1%; p=0.48) between the groups.
  • Lower gestational age (median 25 4/7 weeks) and male sex were significantly associated with catheter colonization (p=0.01).

Conclusions:

  • The use of antibiotic and antimycotic impregnated PICC-lines in neonates showed a trend towards reduced colonization but did not reach statistical significance.
  • Lower gestational age and male sex are confirmed as significant risk factors for PICC colonization in this population.
  • Further research may be needed to confirm the clinical utility of impregnated PICC-lines in neonates.