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Updated: Jan 5, 2026
07:52
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
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Morphologic Patterns and the Correlation With MYD88 L265P, CD79B Mutations in Primary Adrenal Diffuse Large B-Cell
Zihang Chen1, Yan Zou, Weiping Liu
1Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
The American Journal of Surgical Pathology
|October 15, 2019
Summary
Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is rare, often affecting older males. Genetic mutations like MYD88 and CD79B are common and influence prognosis, leading to a new classification system.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is a rare extranodal lymphoma.
- Limited understanding of its clinicopathologic and genetic features due to rarity.
Purpose of the Study:
- To systematically review clinicopathologic features of PA-DLBCL.
- To investigate the frequency of MYD88 L265P and CD79B mutations.
- To propose a novel Histo-Molecular Classification system.
Main Methods:
- Systematic review of 42 PA-DLBCL cases.
- Sanger sequencing for MYD88 L265P and CD79B mutations in 29 cases.
- Correlation of morphologic and genetic findings with clinical outcomes.
Main Results:
- PA-DLBCL predominantly affects elderly males with advanced stage and poor outcomes.
- High prevalence of MYD88 L265P (24%) and CD79B mutations (52%).
- CD79B mutation associated with worse prognosis; proposed classification system correlates morphology with genetics and survival.
Conclusions:
- PA-DLBCL exhibits distinct clinicopathologic and genetic features.
- A novel Histo-Molecular Classification aids in risk stratification and prognosis.
- Further research is needed to validate findings and extend to other extranodal sites.
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