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Psoriasis in family members of patients with multiple sclerosis

Olivia Charlton1, Kevin Phan2, Saxon D Smith3

  • 1Lotus Dermatology, Newcastle, Australia.

Multiple Sclerosis and Related Disorders
|October 15, 2019
PubMed
Abstract

Insights

Family members of individuals with multiple sclerosis (MS) have an increased risk of developing psoriasis. This finding suggests a potential genetic link between these autoimmune conditions.

Area of Science:

  • Autoimmune disease research
  • Genetics of autoimmune disorders
  • Epidemiology of neurological and dermatological conditions

Background:

  • Anecdotal evidence and some studies suggest a link between multiple sclerosis (MS) and psoriasis.
  • The exact nature of the association between MS and psoriasis remains unclear.
  • Familial clustering of autoimmune diseases may indicate shared genetic factors.

Purpose of the Study:

  • To investigate the association between multiple sclerosis and psoriasis.
  • To determine if family members of MS patients have an increased risk of psoriasis.

Main Methods:

  • Systematic review and meta-analysis conducted following PRISMA guidelines.
  • Extracted data from studies comparing psoriasis incidence in relatives of MS cases versus control cases.
  • Pooled unadjusted meta-analysis of 5 eligible studies.

Main Results:

  • Family members of MS patients showed an increased risk of psoriasis.
  • The odds ratio for psoriasis in relatives of MS patients was 1.45 (95% CI 1.07, 1.97).

Conclusions:

  • Family members of individuals with multiple sclerosis may be at a higher risk of developing psoriasis.
  • The findings suggest a potential shared genetic or etiological basis for MS and psoriasis.
Keywords:
Autoimmune diseaseMultiple sclerosisPsoriais

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