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Diffusional kurtosis imaging of kidneys in patients with hyperuricemia: initial study
Zhong-Yuan Cheng1,2, You-Zhen Feng1,2, Xiao-Ling Liu3
1Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, PR China.
Acta Radiologica (Stockholm, Sweden : 1987)
|October 16, 2019
Summary
Diffusion kurtosis imaging shows promise for detecting early renal changes in hyperuricemia patients. This technique may help monitor kidney function when traditional indicators are lacking.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Reliable indicators for monitoring renal function in hyperuricemia patients are currently lacking.
- Hyperuricemia is associated with kidney disease, necessitating improved assessment methods.
Purpose of the Study:
- To evaluate the feasibility of diffusion kurtosis imaging (DKI) for assessing renal function in hyperuricemia.
- To investigate early renal changes in patients with asymptomatic hyperuricemia and gouty arthritis using DKI.
Main Methods:
- DKI data were acquired from 75 male participants (25 asymptomatic hyperuricemia, 25 gouty arthritis, 25 controls).
- Key DKI parameters (Ka, Kr, MK) and diffusion tensor imaging parameters (FA, Da, Dr, MD) were derived.
- Parameters were compared among groups and correlated with estimated glomerular filtration rate (eGFR).
Main Results:
- Mean kurtosis (MK) and radial kurtosis (Kr) were significantly elevated in hyperuricemia groups compared to controls.
- Gouty arthritis patients exhibited higher axial kurtosis (Ka) values.
- No significant correlation was observed between DKI parameters and eGFR.
Conclusions:
- Diffusion kurtosis imaging is a feasible technique for assessing early renal cortex and medulla changes in hyperuricemia.
- DKI may offer a novel approach to monitor kidney health in individuals with elevated uric acid levels.
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