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Complement Inhibitors in Clinical Trials for Glomerular Diseases.
Peter F Zipfel1,2, Thorsten Wiech3, Ramona Rudnick1
1Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Frontiers in Immunology
|October 16, 2019
Summary
Defective complement action contributes to numerous human glomerular diseases. This review summarizes ongoing clinical trials for complement inhibitors across nine kidney disorders, detailing the specific inhibitors under investigation.
Area of Science:
- Nephrology
- Immunology
- Complement System
Background:
- Defective complement system activity is implicated in the pathogenesis of various human glomerular diseases.
- These kidney disorders include atypical hemolytic uremic syndrome (aHUS), ANCA-associated vasculitis, C3 glomerulopathy, IgA nephropathy, and lupus nephritis, among others.
Purpose of the Study:
- To review ongoing clinical trials investigating complement inhibitors for glomerular diseases.
- To identify the specific complement inhibitors being evaluated in clinical trials for these renal conditions.
Main Methods:
- Systematic review of clinical trials registered on http://clinicaltrials.gov.
- Identification and categorization of complement inhibitors used in trials for nine specific glomerular diseases.
Main Results:
- Multiple complement inhibitors are under investigation across nine distinct glomerular diseases.
- The specific types of complement inhibitors vary depending on the targeted renal disorder.
Conclusions:
- Complement inhibition represents a promising therapeutic strategy for a range of glomerular diseases.
- Further research and clinical trials are essential to establish the efficacy and safety of these inhibitors in treating kidney disorders.
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