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Platelet activation in psoriasis.

M Berrettini, P Parise, V Constantini

    Thrombosis and Haemostasis
    |April 22, 1985
    PubMed
    Summary
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    Psoriasis patients show increased platelet activation, indicated by higher spontaneous platelet hyperaggregability and beta-thromboglobulin levels. This platelet activation may contribute to thrombotic vascular disease risk in psoriasis.

    Area of Science:

    • Dermatology
    • Hematology
    • Vascular Medicine

    Background:

    • Psoriasis is increasingly recognized as a risk factor for thrombotic vascular diseases.
    • Understanding the hemostatic changes associated with psoriasis is crucial for evaluating thrombotic risk.

    Purpose of the Study:

    • To investigate hemostatic parameters in male psoriatic patients compared to controls.
    • To evaluate the role of hemostatic changes in the development of thrombotic episodes in psoriasis.

    Main Methods:

    • Compared hemostatic parameters in 22 male psoriatic patients and 22 male controls.
    • Assessed platelet count, circulating platelet aggregates, malondialdehyde (MDA) production, antithrombin, and fibrinolytic activities.
    • Measured spontaneous platelet hyperaggregability, plasma beta-thromboglobulin, and platelet regeneration time (MDA recovery after aspirin).

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    Main Results:

    • No significant differences in platelet count, circulating aggregates, MDA production, antithrombin, or fibrinolytic activity.
    • Significantly higher spontaneous platelet hyperaggregability and plasma beta-thromboglobulin in psoriatic patients.
    • Significantly shorter platelet regeneration time in psoriatic patients.

    Conclusions:

    • In vivo platelet activation occurs in patients with psoriasis.
    • Platelet activation may contribute to thrombotic complications in psoriasis.
    • Released substances from activated platelets might influence the histogenesis of psoriatic lesions.