Palliative care utilization in hospitalized children with cancer

Brian T Cheng1, Tenzin Wangmo2

  • 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Pediatric Blood & Cancer
|October 16, 2019
PubMed

Insights

Palliative care (PC) is used in only 4.4% of pediatric cancer hospitalizations, despite its benefits. Utilization varies by cancer type and patient age, impacting costs and highlighting a need for better assessment tools.

Area of Science:

  • Pediatric Oncology
  • Palliative Care Research
  • Health Services Research

Background:

  • Growing evidence supports palliative care (PC) to improve quality of life in pediatric cancer patients.
  • Despite recommendations, patterns of PC utilization in pediatric oncology remain understudied.

Purpose of the Study:

  • To investigate the utilization patterns of palliative care (PC) among children with cancer and high in-hospital mortality risk.
  • To identify factors associated with PC involvement and its impact on healthcare costs.

Main Methods:

  • Analysis of the 2005-2011 National Inpatient Sample, a large US hospital admissions database.
  • Inclusion of 10,960 hospitalizations for children with cancer and high mortality risk.
  • Use of survey-weighted regression models to assess PC involvement predictors and costs.

Main Results:

  • Palliative care (PC) was involved in 4.4% of pediatric cancer hospitalizations.
  • Shorter length of stay, solid tumors, and older age were associated with PC use.
  • PC utilization correlated with lower overall and daily hospital costs.

Conclusions:

  • Palliative care (PC) is underutilized in pediatric cancer patients at high risk of mortality.
  • Utilization disparities exist across socio-economic groups, impacting resource allocation.
  • Further research is needed to develop tools for optimal PC assessment in pediatric oncology.
Abstract

Related Concept Videos

Continuing Care01:25

Continuing Care

Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
1.8K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
227
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
163
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
620
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K