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Biocompatibility in regenerative nanomedicine
Fatih Zor1, Fatma Nurefsan Selek1, Giuseppe Orlando2
1Department of Surgery, Wake Forest University Health Sciences, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA.
Nanomedicine (London, England)
|October 16, 2019
Summary
Biocompatibility, crucial for biomaterials, remains unclear, especially with nanoparticles (NP). This study reviews NP biocompatibility challenges in nanomedicine, highlighting their variable interactions within the body.
Area of Science:
- Biomaterial Science
- Nanotechnology
- Nanomedicine
Background:
- Biocompatibility defines foreign material interactions with the body but lacks clear definition and mechanistic understanding.
- Nanotechnology introduces new biocompatibility concerns due to nanoparticle (NP) properties.
- NP behavior, including distribution and cellular interactions, is highly variable.
Purpose of the Study:
- To provide an overview of nanoparticles (NPs).
- To clarify the concept of biocompatibility.
- To discuss biocompatibility-related issues in nanomedicine concerning various NPs.
Main Methods:
- Literature review on biocompatibility.
- Analysis of nanoparticle properties and their impact.
- Discussion of nanomedicine applications and challenges.
Main Results:
- The definition and mechanisms of biocompatibility require further elucidation.
- Nanoparticle characteristics significantly influence their biological interactions.
- Understanding NP biocompatibility is critical for safe nanomedicine development.
Conclusions:
- Further research is needed to establish clear definitions and mechanisms for NP biocompatibility.
- Careful consideration of NP properties is essential for successful nanomedicine applications.
- Addressing biocompatibility challenges is paramount for advancing nanomedicine.
