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Updated: Jan 5, 2026
Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Photoinduced Deoxygenative Borylations of Aliphatic Alcohols
Jingjing Wu1, Robin M Bär1, Lin Guo1
1School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Abstract:
A photochemical method for converting aliphatic alcohols into boronic esters is described. Preactivation of the alcohol as a 2-iodophenyl-thionocarbonate enables a novel Barton-McCombie-type radical deoxygenation that proceeds efficiently with visible light irradiation and without the requirement for a photocatalyst, a radical initiator, or tin or silicon hydrides. The resultant alkyl radical is intercepted by bis(catecholato)diboron, furnishing boronic esters from a diverse range of structurally complex alcohols.
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