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Updated: Jan 5, 2026
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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
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Metal-Ligand Coordination Nanomaterials for Biomedical Imaging
Xiangli Li1, Zheng Cai1, Li-Ping Jiang1
1State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering , Nanjing 210023 , P. R. China.
Bioconjugate Chemistry
|October 16, 2019
Summary
Nanoscale coordination polymers (NCPs) and metal-organic frameworks (NMOFs) are versatile nanomaterials for advanced biomedical imaging. This review highlights their recent progress and future potential in various imaging modalities.
Area of Science:
- Nanomaterials Science
- Biomedical Engineering
- Radiology
Background:
- Amorphous nanoscale coordination polymers (NCPs) and crystalline nanoscale metal-organic frameworks (NMOFs) have gained prominence in biomedical applications.
- Their biodegradability, tunable composition, and functionalizability make them suitable for drug delivery, biomedical imaging, and biosensing.
Purpose of the Study:
- To review recent advances in NCPs/NMOFs for biomedical imaging, focusing on research from the past three years.
- To discuss various imaging technologies utilizing NCPs/NMOFs and their application in multimodal imaging.
Main Methods:
- Literature review of recent research on NCPs/NMOFs in biomedical imaging.
- Analysis of applications in magnetic resonance (MR), positron emission tomography (PET), computed tomography (CT), optical, and photoacoustic (PA) imaging.
- Focus on multimodal imaging, particularly optical/MR combinations.
Main Results:
- NCPs/NMOFs serve as effective contrast agents and nanocarriers across multiple imaging modalities.
- Recent research demonstrates significant progress in their application for enhanced diagnostic capabilities.
- Multimodal imaging strategies utilizing NCPs/NMOFs show promise for comprehensive patient assessment.
Conclusions:
- NCPs/NMOFs represent a rapidly evolving field with substantial potential in biomedical imaging.
- Further research is needed to address challenges and unlock future prospects for these nanomaterials.
- Continued development is crucial for optimizing NCPs/NMOFs for clinical translation.
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