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Updated: Jan 5, 2026
09:43
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
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Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration.
Cristina Grange1, Renata Skovronova2, Federica Marabese3,4
1Department of Medical Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy. cristina.grange@unito.it.
Cells
|October 17, 2019
Summary
Mesenchymal stromal cell-derived extracellular vesicles (EVs) show regenerative potential for kidney injury. This review explores their therapeutic applications in preclinical models and ongoing clinical trials for renal damage.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cell Biology
Background:
- Extracellular vesicles (EVs) are cell-derived vesicles mediating intercellular communication.
- Stem cell-derived EVs, particularly from mesenchymal stromal cells (MSCs), exhibit therapeutic promise.
- EVs are implicated in modulating pathophysiological conditions, including kidney injury.
Purpose of the Study:
- To review the therapeutic applications of MSC-EVs in preclinical models of acute and chronic kidney injury.
- To discuss the mechanisms underlying MSC-EVs' regenerative effects in renal damage.
- To highlight ongoing clinical trials and future strategies for enhancing MSC-EV efficacy.
Main Methods:
- Literature review of preclinical studies on MSC-EVs in kidney injury models.
- Analysis of data from ongoing clinical trials involving MSC-EVs.
- Discussion of EV engineering strategies for improved therapeutic outcomes.
Main Results:
- MSC-EVs demonstrate regenerative potential in various kidney injury models.
- Mechanisms include cellular reprogramming, proliferation, angiogenesis, and anti-apoptotic/anti-inflammatory effects.
- Clinical trials are investigating MSC-EVs for renal conditions and transplant conditioning.
Conclusions:
- MSC-EVs represent a promising cell-free therapeutic strategy for kidney diseases.
- Further research and clinical validation are essential to optimize their use.
- EV engineering holds potential for enhancing therapeutic efficacy in renal repair.
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