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Updated: Aug 12, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
[Electro-vectorcardiographic aspects of diastolic and mixed overloads of the right ventricle]
Insights
This study on atrial septal defects found that right ventricular conduction disturbances are common. Electrocardiographic patterns can help classify block types and assess right ventricular diastolic overload.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Context:
- Atrial septal defect (ASD) diagnosis and management.
- Understanding right ventricular conduction disturbances in ASD patients.
- Utilizing electrovectorcardiography for cardiac assessment.
Purpose:
- To analyze electrovectorcardiographic findings in 400 isolated atrial septal defect cases.
- To correlate conduction disturbances with ventricular depolarization and repolarization.
- To investigate the relationship between right ventricular diastolic overload and Q-Tc interval prolongation.
Summary:
- Diagnosed 400 isolated atrial septal defect cases using hemodynamic and surgical data.
- Recorded thoracic and intracardiac electrograms, and vectorcardiograms.
- Identified various right ventricular conduction disturbances in all cases.
- Analyzed electrovectorcardiographic aspects of ventricular depolarization and repolarization.
- Determined mean vector angles at 60 ms of ventricular activation.
- Differentiated right proximal and distal blocks based on specific wave patterns.
- Observed monofascicular and parietal right blocks in low diastolic overload states.
- Used anterior inferior right septal mass activation time for block classification.
- Linked prolonged Q-Tc interval in right leads to right ventricular diastolic overload magnitude.
Impact:
- Provides insights into diagnosing and classifying right ventricular conduction disturbances in ASD.
- Enhances understanding of electrovectorcardiographic markers for right ventricular diastolic overload.
- Contributes to improved diagnostic accuracy and patient stratification for ASD.
Abstract:
We studied 400 cases of isolated atrial septal defect without severe pulmonary hypertension, in which the diagnosis was established by the hemodynamic data and it was proven by surgical findings in 257 instances. High fidelity unipolar thoracic and intracardiac records, as well as vectorcardiographic curves in three planes, were obtained. Different types of right ventricular conduction disturbances, which were present in all cases, as well as certain electro-vectorcardiographic aspects related to ventricular depolarization and repolarization, were analyzed. Mean angles of the resulting vectors at 60 msc of the ventricular activation, were determined relating to the types of block. The following points should be emphasized: Besides the right proximal blocks, which are more frequent, right distal ones can also be diagnosed by the presence of slurred R wave and delayed onset of the intrinsicoid deflection in only some right leads. The monofascicular and parietal right blocks are observed when the diastolic overload of the ipsilateral ventricle is low. The activation time of the anterior inferior right septal mass generally permits an objective classification of the degree of a right proximal block. The prolonged Q-Tc interval only in right leads, seems to be a function of the magnitude of the right ventricular diastolic overload.
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