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Cortical Visual Evoked Potentials and Growth in Infants Fed with Bioactive Compounds-Enriched Infant Formula: Results

Ana Nieto-Ruiz1,2,3, José Antonio García-Santos4,5, Mercedes G Bermúdez6,7

  • 1EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain. ananietoruiz@gmail.com.

Nutrients
|October 17, 2019
PubMed

Insights

This study found that an enriched infant formula did not improve growth or neurodevelopment compared to standard formula. However, it showed potential in improving visual function (VF) in infants, nearing breastfed levels.

Area of Science:

  • Pediatrics
  • Nutrition Science
  • Developmental Neuroscience

Background:

  • Postnatal nutrition significantly impacts infant growth and neurodevelopment.
  • Bioactive compounds in infant formula may influence developmental outcomes.
  • Visual function (VF) is a key indicator of neurodevelopment in early life.

Purpose of the Study:

  • To evaluate the effect of a novel enriched infant formula (EF) with bioactive compounds on infant growth, neurodevelopment, and visual function (VF).
  • To compare outcomes between infants receiving EF, standard formula (SF), and breastfed (BF) infants.
  • To assess the potential of nutritional interventions to bridge developmental gaps.

Main Methods:

  • A randomized clinical trial (RCT) involving 170 healthy infants over 18 months.
  • Infants were assigned to receive either SF or EF (n=85 each).
  • Growth was monitored, neurodevelopment assessed via general movements (2-4 months), and VF measured using cortical visual evoked potentials (3 and 12 months).
  • A control group of 50 breastfed infants (BF) was included for comparison.

Main Results:

  • No significant differences in growth or neurodevelopment were observed between the SF and EF groups.
  • Both SF and EF groups exhibited prolonged P100 wave latencies and lower amplitudes compared to the BF group.
  • The EF group showed improved visual response at 12 months compared to 3 months, with outcomes approaching those of breastfed infants.

Conclusions:

  • While the enriched formula did not alter general growth or neurodevelopment, it demonstrated a positive impact on visual function development.
  • Nutritional interventions with bioactive compounds may help reduce disparities in visual development between formula-fed and breastfed infants.
  • Further research is warranted to fully understand the long-term benefits of enriched formulas on infant development.

Keywords:
bioactive compoundsbreastfeedinggrowthinfant formulavisual evoked potentials

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