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Published on: April 11, 2016
Precision oncology: lessons learned and challenges for the future.
Hsih-Te Yang1, Ronak H Shah1,2, David Tegay1
1Medical Genetics and Human Genomics, Department of Pediatrics, Northwell Health, New York, NY, USA.
Precision medicine programs leverage genomic profiling for real-time cancer treatment. This review examines current precision oncology, highlighting benefits and challenges for future optimization.
Area of Science:
- Genomics
- Oncology
- Personalized Medicine
Background:
- Advancements in DNA sequencing enable large-scale genomic studies.
- Healthcare institutions are implementing precision medicine programs to translate genomic findings into clinical practice.
- Cancer serves as a model for genetic diseases, driving the need for real-time genetic profiling.
Purpose of the Study:
- To review the current state of precision oncology.
- To identify challenges and benefits of precision medicine programs.
- To offer suggestions for optimizing future precision oncology initiatives.
Main Methods:
- Review of current precision oncology landscape.
- Analysis of "first-generation" precision oncology program outcomes.
- Identification of challenges and benefits through case examples.
Main Results:
- Precision medicine programs integrate patient enrollment, electronic health records, biobanking, and results return.
- Real-time genetic profiling is crucial for tailoring cancer therapies.
- Early adopters provide valuable lessons for program development.
Conclusions:
- Precision oncology offers significant benefits to cancer patients.
- Overcoming implementation challenges is key to widespread adoption.
- Lessons learned from early adopters can guide the optimization of future programs.
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