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Updated: Jan 5, 2026
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Strokectomy and Extensive Cisternal CSF Drain for Acute Management of Malignant Middle Cerebral Artery Infarction:
Fulvio Tartara1, Elena Virginia Colombo1, Daniele Bongetta2
1UO Neurochirurgia, Azienda Ospedaliero-Universitaria, Parma, Italy.
Abstract:
Background and Purpose: Ischemic stroke is a major cause of death and disability worldwide. Large MCA stroke may evolve as malignant space occupying lesion and mortality rate reaches 80% despite maximal medical therapy. Early decompressive craniectomy is effective in reducing mortality and improving the functional outcome but is an extended and invasive surgical approach burdened with a significant complication rate. We report a surgical treatment based on partial strokectomy and basal cisterns opening with massive CSF drain. Materials and Methods: We retrospectively collected 15 cases of massive middle cerebral artery stroke treated with strokectomy between 2010 and 2017: nine males and six females, mean age 61.73 ± 9.5 years. The right side was affected in 66.7%. All patients show clinical deterioration despite standard medical therapy and indication for surgery was placed after collegiate evaluation by neurologists and neurosurgeons based on clinical and radiological data. Results: Surgical procedure was performed 24-96 h after the stroke onset. All the 15 patients survived the intervention, one patient died 20 days after the admission for massive lung embolism. Mean GCS and NIHSS at admission were 12.6 ± 1.18 (range 9-15) and 19.7 ± 2.3 (range 18-23), respectively. Mean mRS at 12 months was 3.6 ± 1.1 (range 2-6). Mean follow-up was 18.1 months (range 12-34). The outcome was evaluated as satisfactory (mRs ≤ 3) in 8 patients (53.3%). Mortality at 1 year was 6.7%. No patients developed hydrocephalus and 1 presented seizures. According to mRs outcome evaluation (mRs ≤ 3 vs. mRs ≥ 4) no quantitative variable resulted significantly different between the two groups, whereas the concomitant use of iv rTPA significantly differed (P < 0.05). Conclusion: Supratentorial strokectomy seems to be safe and could be a potential alternative to decompressive craniectomy for the acute management of malignant MCA stroke. Advantages of this approach could be low complication rate, avoidance of bone reconstruction procedure, and reduced occurrence of hydrocephalus or seizures. A co-operative multicentric, prospective pilot study will be necessary to validate this technical approach.
Insights
This study introduces partial strokectomy with basal cisterns opening as a safer alternative to decompressive craniectomy for malignant middle cerebral artery (MCA) stroke, showing promising outcomes and reduced complications.
Area of Science:
- Neurosurgery
- Neurology
- Vascular Surgery
Background:
- Ischemic stroke, particularly large middle cerebral artery (MCA) strokes, poses a significant global health burden, often leading to malignant space-occupying lesions and high mortality rates.
- While decompressive craniectomy can reduce mortality, it is invasive and associated with considerable complications.
- A novel surgical approach involving partial strokectomy and basal cisterns opening is explored as a potentially less invasive alternative.
Purpose of the Study:
- To evaluate the safety and efficacy of partial strokectomy with basal cisterns opening in patients with massive MCA stroke.
- To compare the outcomes of this technique with traditional treatments for malignant MCA stroke.
Main Methods:
- A retrospective analysis of 15 patients with massive MCA stroke treated between 2010 and 2017 using partial strokectomy and basal cisterns opening.
- Patients underwent surgery 24-96 hours after stroke onset, with outcomes assessed using the modified Rankin Scale (mRS) at 12 months.
Main Results:
- All 15 patients survived the surgical intervention, with a 1-year mortality rate of 6.7%.
- A satisfactory outcome (mRS ≤ 3) was achieved in 53.3% of patients.
- The procedure demonstrated a low complication rate, with no cases of hydrocephalus and only one instance of seizures.
Conclusions:
- Partial strokectomy with basal cisterns opening appears to be a safe and effective alternative for managing acute malignant MCA stroke.
- This technique offers potential advantages over decompressive craniectomy, including a lower complication rate and avoidance of bone reconstruction.
- Further validation through multicentric, prospective studies is warranted to confirm the benefits of this surgical approach.
