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Updated: Jan 5, 2026
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
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A 63-Year-Old Male with AIDS and Diffuse Violaceous Plaques
Travis A Benson1, Patrick M Mulvaney2, Mai P Hoang3
1Harvard Medical School, Boston, Massachusetts, USA.
Dermatopathology (Basel, Switzerland)
|October 17, 2019
Summary
This study describes a rare case of hyperkeratotic Kaposi's sarcoma (KS) in an HIV-positive male. The findings highlight the distinct histopathological features of this AIDS-related KS variant.
Area of Science:
- Oncology
- Dermatology
- Infectious Diseases
Background:
- AIDS-related Kaposi's sarcoma (KS) is an opportunistic malignancy.
- Hyperkeratotic KS is a rare clinicopathologic variant.
- It typically manifests with chronic lymphedema and hyperkeratotic plaques on the lower extremities.
Observation:
- A 63-year-old HIV-positive male presented with symptoms consistent with hyperkeratotic KS.
- The patient exhibited chronic lymphedema and diffuse hyperkeratotic plaques.
Findings:
- Histopathological examination revealed epidermal hyperplasia.
- Thickened lymphatic walls and increased dermal fibroblasts and vascular spaces were observed.
- These findings confirm the diagnosis of hyperkeratotic Kaposi's sarcoma.
Implications:
- This case adds to the understanding of rare KS variants in HIV-positive individuals.
- Recognizing hyperkeratotic KS is crucial for appropriate diagnosis and management.
- Further research into the pathogenesis and treatment of this variant may be warranted.
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