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Related Experiment Video

Updated: Jan 30, 2026

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
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Lymphocyte aberrations in ankylosing spondylitis.

H C Liu

    Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
    |February 1, 1985
    PubMed
    Summary

    Ankylosing spondylitis (AS) patients show altered immune cell counts and function, with decreased T-cells and impaired responses. These changes, particularly evident in active disease, suggest T-cell immune aberrations may contribute to B-cell hyperreactivity in AS.

    Area of Science:

    • Immunology
    • Rheumatology
    • Cellular Biology

    Background:

    • The cause of elevated IgA and IgG in ankylosing spondylitis (AS) is unknown.
    • Cellular immune system alterations are suspected in AS pathogenesis.

    Purpose of the Study:

    • To investigate lymphocyte subpopulations and immune function in AS patients.
    • To explore the relationship between T-cell and B-cell responses in AS.

    Main Methods:

    • Measured lymphocyte counts and subpopulations (T-cells, B-cells) in 50 AS patients and 40 controls.
    • Assessed cellular immune function via mitogen-induced proliferation (Con A, PHA, PWM) and autologous mixed lymphocyte reaction (AMLR).

    Main Results:

    • AS patients exhibited significantly lower lymphocyte, total T, active T, OKIa1, OKT3, OKT4, and OKT8 cells compared to controls.

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  • A decreased OKT4/OKT8 ratio was observed, alongside hyperreactivity to PWM (B-cell mitogen) and depressed response to Con A (T-cell mitogen).
  • Impaired AMLR and normalization of parameters in inactive disease stages were noted.

    • Conclusions:

    • T-cell immune aberrations, including depressed lymphoproliferative response to Con A and impaired AMLR, may underlie B-cell hyperreactivity in AS.
    • These immune dysregulations appear linked to the active stage of ankylosing spondylitis.