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Is Helicobacter pylori associated with Behçet's syndrome? A meta-analysis
Ye Yu1, Xin Yao2, Junyu Liang1
1Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Insights
Behçet's syndrome patients have a higher rate of Helicobacter pylori infection. Eradicating H. pylori can improve symptoms like oral and genital ulcers, suggesting a potential causal link.
Area of Science:
- Gastroenterology
- Immunology
- Infectious Diseases
Background:
- Controversy exists regarding the association between Helicobacter pylori (H. pylori) infection and Behçet's syndrome (BS).
- Previous studies have explored this relationship, necessitating further clarification.
Purpose of the Study:
- To conduct a meta-analysis to elucidate the relationship between H. pylori infection and BS.
- To determine if H. pylori eradication impacts BS clinical manifestations.
Main Methods:
- A systematic literature search was performed in PubMed, MEDLINE, and Embase up to July 1, 2019.
- Six relevant English-language studies were included based on predefined criteria.
- Statistical data were extracted and analyzed to assess the association and treatment effects.
Main Results:
- Behçet's syndrome patients demonstrated a 1.39-fold increased susceptibility to H. pylori infection.
- Significant improvements were observed in oral ulceration, genital ulceration, and cutaneous lesions following H. pylori eradication.
- Publication bias and sensitivity analyses confirmed the statistical robustness of the findings, indicating no significant heterogeneity.
Conclusions:
- Behçet's syndrome patients exhibit a higher prevalence of H. pylori infection.
- H. pylori eradication is associated with the improvement of key clinical symptoms in BS patients.
- These findings suggest H. pylori may play an etiological role in the development of Behçet's syndrome.
Background:
Preceding studies have reported the relationship between Helicobacter pylori (H pylori) and Behçet's syndrome (BS), but there still exists controversy. In this study, we firstly conducted a meta-analysis to clarify the relationship of these two diseases.
Methods:
Articles published until July 1, 2019, in the PubMed, MEDLINE, and Embase databases with restriction of English-language studies were searched and reviewed. According to the inclusion criteria, relevant statistical data were extracted and analyzed.
Results:
Six articles were finally included. The result showed that BS individuals were 1.39 times more susceptible to H pylori infection (OR = 1.39, 95% CI = (1.03, 1.87)). In addition, it found that oral ulceration (OR = 27.98, 95% CI = (3.49, 224.49)), genital ulceration (OR = 3.15, 95% CI = (1.51, 6.56)), and cutaneous lesions (OR = 4.29, 95% CI = (2.14, 8.61)) were alleviated after H pylori eradication. Publication bias and sensitivity analysis showed no statistical heterogeneity.
Conclusions:
BS patients had higher rate of H pylori infection, and clinical symptoms including oral ulceration, genital ulceration, and cutaneous lesions can be improved after H pylori eradication. The results indicated that H pylori may be an etiological factor to BS.
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