ON/OFF Control of the Flipping Motion of Diuranyl Bis(Salophen) Macrocycle by Extremely Strong Binding with Fluoride
Massimo Cametti1, Yoko Sakata2, Javier Martí-Rujas1,3
1Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta" , Politecnico di Milano , Via Luigi Mancinelli 7 , Milan 20131 , Italy.
Abstract:
Diuranyl bis(salophen) complex 1 features a relatively slow conformational motion, induced by an intramolecular O═U═O···UO2 binding motif, which interconverts the two nonsymmetric halves of the ligand. This flipping motion, which constitutes one of the fundamental molecular motions, can be completely halted by addition of fluoride anion, which is bound to 1, reaching one of the highest affinities reported to date. This system represents a model to study flipping dynamics in light of the possibility of developing novel types of molecular machines based on it.
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
Antihypertensive Drugs: Potassium-Sparing Diuretics
Antihypertensive Drugs: Action of Calcium Channel Blockers
Solubility Equilibria: Overview
Solubility is important in biological and environmental processes. A notable...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
Drug Elimination by Renal Route: Tubular Reabsorption


