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Updated: Jan 5, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
β-Cell senescence in the pathogenesis of type 2 diabetes
1Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Abstract:
The prevalence of type 2 diabetes increases with aging, and the type 2 diabetes developing in the elderly is often accompanied by a gradual impairment of β-cell function and reduced β-cell mass along with aging. However, the contribution of β-cell senescence to the pathogenesis of type 2 diabetes remains uncertain. In a recent Cell Metabolism article, Aguayo-Mazzucato et al. described their efforts to identify the signatures of senescent β-cells, and explored the role(s) of senescent β-cells in type 2 diabetes.
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