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The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
Marco A Mascarella1,2, Lorne Schweitzer3, Mahmoud Alreefi1
1Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada.
Background:
Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events.
Case Presentation:
We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy.
Conclusion:
Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.
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