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Published on: November 19, 2019
Risk factors for venous thromboembolism in individuals undergoing coronary artery bypass grafting
Wenting Du1, Xiaojie Zhao2, Andrew Nunno3
1Department of Geriatrics, Affiliated Longhua Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China; Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Insights
Venous thromboembolism (VTE) after coronary artery bypass grafting (CABG) is uncommon but linked to severe complications. Key risk factors include bleeding disorders, heart failure, and long operative times, guiding preventative strategies.
Area of Science:
- Cardiovascular Surgery
- Thrombotic Disorders
- Patient Outcomes
Background:
- Venous thromboembolism (VTE) is a significant concern following major surgical procedures.
- Coronary artery bypass grafting (CABG) carries a risk of postoperative VTE, necessitating investigation into its incidence and predictors.
Purpose of the Study:
- To determine the incidence of VTE after CABG.
- To identify risk factors associated with VTE development post-CABG.
- To analyze the complications and outcomes in patients experiencing VTE after CABG.
Main Methods:
- Analysis of the American College of Surgeons National Surgical Quality Improvement Program database (2012-2015).
- Inclusion of patients who underwent CABG.
- Statistical analysis including single-factor and binary logistic regression to identify risk factors and complications.
Main Results:
- The incidence of VTE post-CABG was 1.75%, with pulmonary embolism at 0.61% and deep vein thrombosis at 1.28%.
- Independent risk factors for VTE included a history of bleeding disorders, congestive heart failure, and operative time ≥310 minutes.
- VTE was associated with significantly worse outcomes, including increased rates of reoperation, hospitalization, and various severe postoperative complications.
Conclusions:
- The overall VTE rate after CABG is low but associated with poorer 30-day outcomes and increased complications.
- History of bleeding disorders, recent congestive heart failure, and prolonged operative time are independent predictors of VTE.
- Identifying these risk factors can inform clinical decisions regarding VTE prophylaxis and management strategies.
Objective:
Venous thromboembolism (VTE) can easily occur after coronary artery bypass grafting (CABG). We assessed the proportion of patients with a diagnosis of VTE after CABG and determined the associated risk factors and complications in these patients.
Methods:
We assessed all the patients included in the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2015 who had undergone CABG. The demographic characteristics, surgical parameters, and complications were analyzed using single-factor and binary logistic regression analyses to identify the risk factors for VTE after CABG.
Results:
Overall, 8956 patients were identified. Postoperative VTE was found in 1.75% of these patients, with pulmonary embolism and deep vein thrombosis accounting for 0.61% and 1.28%, respectively; 0.15% of the patients had both conditions. The patients who had developed VTE had greater odds of being white and having an American Society of Anesthesiologists classification of ≥5. Multivariate analysis showed that a history of bleeding disorders, congestive heart failure, and operative time of ≥310 minutes were risk factors for the development of postoperative VTE. Patients with VTE had worse outcomes, including greater odds of returning to the operating room, hospitalization, unplanned reoperation, and readmission. The occurrence of VTE was associated with several postoperative complications, including emergency intubation, ventilator time >48 hours, pneumonia, urinary tract infection, peri- and postoperative transfusions, gradual kidney function reduction, acute kidney failure, cardiac arrest necessitating cardiopulmonary resuscitation, myocardial infarction, and septic shock.
Conclusions:
The overall VTE rate after CABG has been low. However, the condition has been associated with worse 30-day postoperative outcomes and complications. The independent predictors of VTE development included a history of bleeding disorders, congestive heart failure in the 30 days before surgery, and operative time of ≥310 minutes. Understanding these risk factors should aid physicians in the decisions regarding prophylaxis and treatment.
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