Iron III isomaltose induced hypersensitivity reaction

Area of Science:

• Clinical Medicine
• Pharmacology
• Immunology

Background:

• Iron isomaltose is a widely used intravenous iron formulation, often considered safe with no routine test dose required.
• Intravenous iron therapies are essential for managing iron deficiency anemia, a common global health issue.

Observation:

• A 35-year-old woman experienced a hypersensitivity reaction, including wheezing and hypoxia, after receiving iron isomaltose.
• The patient's symptoms rapidly improved following administration of oxygen, acetaminophen, chlorphenaramine, and hydrocortisone.

Findings:

• This case demonstrates that iron isomaltose, despite its safety profile, can precipitate allergic reactions.
• Prompt recognition and management of hypersensitivity are critical for patient safety during intravenous iron administration.

Implications:

• Healthcare facilities must be equipped to manage potential anaphylactic or hypersensitivity reactions to intravenous iron.
• Clinicians should remain vigilant for adverse events associated with iron isomaltose and other intravenous iron products.