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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 5, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Glaucoma Patch Graft Surgery Utilizing Corneas Augmented with Collagen Cross-linking.

Donald U Stone1,2, Earl Randy Craven1,2, Sameer I Ahmad2,3,4

  • 1Department of Research, ReWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Middle East African Journal of Ophthalmology
|October 18, 2019
PubMed
Summary

Corneal tissue treated with UV-riboflavin cross-linking is a safe patch graft for glaucoma drainage device surgery (GDDS), preventing tube erosion. This novel method offers a cost-effective alternative to existing techniques.

Keywords:
Corneacross-linkingglaucoma drainage devicepatch graft

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Glaucoma drainage device surgery (GDDS) is a viable alternative to trabeculectomy.
  • Tube erosion through the conjunctiva occurs in 5-10% of GDDS cases.
  • Donor corneal tissue has been explored as a patch graft to prevent erosion.

Purpose of the Study:

  • To evaluate the safety and efficacy of UV-riboflavin cross-linked corneal lenticules as patch grafts in GDDS.
  • To assess the prevention of tube erosion using this novel graft material.

Main Methods:

  • A prospective proof-of-concept study involved 10 patients undergoing GDDS.
  • Donor corneal lenticules were cross-linked using UV-riboflavin.
  • The cross-linked lenticules were used as patch grafts over the GDDS tube.

Main Results:

  • Histology confirmed full-thickness cross-linking of the corneal grafts without demarcation lines.
  • No intra- or postoperative complications related to the graft tissue were observed.
  • No instances of tube erosion or exposure occurred during the 1-year follow-up.

Conclusions:

  • UV-riboflavin cross-linking of corneal tissue is a safe modification for GDDS patch grafts.
  • This technique shows promise in preventing tube erosion.
  • This method presents a potentially cost-effective alternative to current patch graft options.