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Risk Factors of Transient Cortical Blindness After Cerebral Angiography: A Multicenter Study
Miao Li1, Huaxin Liang1, Chao Liu2
1Department of Neurosurgery, The China-Japan Union Hospital of Jilin University, Changchun, China.
Insights
Transient cortical blindness after cerebral angiography is rare but linked to higher contrast agent doses and posterior circulation injections. Identifying these risk factors is crucial for patient safety.
Area of Science:
- Neurology
- Radiology
- Ophthalmology
Background:
- Transient cortical blindness is a rare but significant complication following cerebral angiography.
- Identifying risk factors for this complication is clinically important for patient management and safety.
Purpose of the Study:
- To identify independent predictive factors for transient cortical blindness after cerebral angiography.
Main Methods:
- A multicenter cohort study involving 5,126 patients who underwent cerebral angiography.
- Analysis of patient baseline characteristics and procedure-related factors using multivariate logistic regression.
Main Results:
- Eighteen patients (0.35%) experienced transient cortical blindness.
- Higher contrast agent dose and injection into the posterior circulation were identified as independent predictive factors (P < 0.05).
- No significant differences were found regarding gender, age, smoking, diabetes, or hypertension.
Conclusions:
- Increased contrast agent dose and posterior circulation contrast injection are potential independent risk factors for transient cortical blindness post-cerebral angiography.
- These findings can inform strategies to mitigate the risk of this complication.
Abstract:
Background: Although transient cortical blindness is a rare complication following cerebral angiography, identification of risk factors for the development of transient cortical blindness after cerebral angiography is an important clinical issue. Material and methods: Between January 2008 and April 2018, 5,126 patients at five high-volume medical centers who underwent cerebral angiography procedures were enrolled in this multicenter cohort study. Patient baseline characteristics and surgery-related factors were analyzed. We used multivariate logistic regression to examine factors associated with transient cortical blindness. Results: Eighteen patients (0.35%) in the total cohort of 5,126 suffered transient cortical blindness. After univariate statistical analysis, no significant differences were determined between the transient cortical blindness group and the control group regarding gender (p = 0.454), age (p = 0.872), smoking (p = 0.170), diabetes (p = 0.800), and hypertension (p = 0.100). Compared with the control group, the transient cortical blindness group weighed less (p = 0.020), and had a larger dose of contrast agent (p = 0.034) and more instances of contrast agent injected into the posterior circulation (p < 0.001). Logistic regression analysis identified contrast agent dose and contrast agent injected into posterior circulation as independent predictive factors for transient cortical blindness (P < 0.05). Conclusion: Larger doses off contrast agent and contrast agent injected into the posterior circulation are potential independent predictive factors for transient cortical blindness following cerebral angiography.
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