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Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
Kun-Hsien Chou1,2, Pei-Ning Wang2,3,4,5, Li-Ning Peng4,6
1Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan.
Frontiers in Neurology
|October 18, 2019
Summary
Arterial pulsatility index (API) is linked to cerebral small vessel disease. This study found that deep/infratentorial cerebral microbleeds (CMBs) associate with internal carotid artery API, while lobar CMBs associate with vertebral artery API.
Area of Science:
- Neurology
- Vascular Medicine
- Radiology
Background:
- Increased arterial pulsatility index (API) is associated with cerebral small vessel disease.
- The relationship between API and cerebral microbleeds (CMBs) requires further investigation.
Purpose of the Study:
- To evaluate the relationship between cerebral microbleeds (CMBs) and arterial pulsatility index (API).
- To explore how CMB location influences the association with API.
Main Methods:
- Cross-sectional study of a community-based population.
- API measured via ultrasonography; CMBs assessed using 3T MRI.
- Participants categorized by CMB location: deep/infratentorial (DI) or strictly lobar (SL).
Main Results:
- 92 of 681 participants had CMBs (57 DI-CMB, 35 SL-CMB).
- DI-CMB associated with elevated internal carotid artery API (p=0.03).
- SL-CMB associated with elevated vertebral artery API (p=0.025).
Conclusions:
- Re-emphasizes the link between API and cerebral small vessel disease.
- Highlights distinct pathogenic differences between DI- and SL-CMBs.
- Suggests subclinical small vascular disorders may occur with CMBs.
Keywords:
arterial pulsatilitycerebral amyloid angiopathycerebral microbleedscerebral small vessel diseasepulsatility index
