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Xylose absorption in Down's syndrome.
Journal of Mental Deficiency Research
|June 1, 1985
Summary
People with Down's syndrome (DS) exhibit significantly impaired xylose absorption compared to other individuals with intellectual disabilities. This malabsorption may contribute to nutrient deficiencies common in DS.
Area of Science:
- Medical Research
- Human Physiology
- Genetics
Background:
- Down's syndrome (DS) is associated with various health complications.
- Nutrient deficiencies are frequently observed in individuals with DS.
- Gastrointestinal function in DS requires further investigation.
Purpose of the Study:
- To assess xylose absorption in individuals with Down's syndrome.
- To compare xylose absorption in DS subjects with age-matched controls with intellectual disabilities.
- To explore potential links between malabsorption and nutrient deficiencies in DS.
Main Methods:
- A standard xylose absorption test was administered.
- Participants included individuals with Down's syndrome and a control group with intellectual disabilities.
- Xylose levels in blood and urine were measured to assess absorption.
Main Results:
- Individuals with intellectual disabilities, as a group, showed impaired xylose absorption.
- Down's syndrome subjects demonstrated significantly reduced xylose absorption compared to controls (P < 0.001).
- Ninety percent of DS subjects had xylose excretion below the normal range.
Conclusions:
- Significant xylose malabsorption is prevalent in individuals with Down's syndrome.
- This malabsorption is more pronounced in DS compared to other intellectual disabilities.
- The identified malabsorption is a likely contributor to vitamin and mineral deficiencies in DS.