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Xylose absorption in Down's syndrome.

C A Williams, H Quinn, E C Wright

    Journal of Mental Deficiency Research
    |June 1, 1985
    PubMed
    Summary
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    People with Down's syndrome (DS) exhibit significantly impaired xylose absorption compared to other individuals with intellectual disabilities. This malabsorption may contribute to nutrient deficiencies common in DS.

    Area of Science:

    • Medical Research
    • Human Physiology
    • Genetics

    Background:

    • Down's syndrome (DS) is associated with various health complications.
    • Nutrient deficiencies are frequently observed in individuals with DS.
    • Gastrointestinal function in DS requires further investigation.

    Purpose of the Study:

    • To assess xylose absorption in individuals with Down's syndrome.
    • To compare xylose absorption in DS subjects with age-matched controls with intellectual disabilities.
    • To explore potential links between malabsorption and nutrient deficiencies in DS.

    Main Methods:

    • A standard xylose absorption test was administered.
    • Participants included individuals with Down's syndrome and a control group with intellectual disabilities.

    Related Experiment Videos

  • Xylose levels in blood and urine were measured to assess absorption.

    • Main Results:

    • Individuals with intellectual disabilities, as a group, showed impaired xylose absorption.
    • Down's syndrome subjects demonstrated significantly reduced xylose absorption compared to controls (P < 0.001).
    • Ninety percent of DS subjects had xylose excretion below the normal range.

    Conclusions:

    • Significant xylose malabsorption is prevalent in individuals with Down's syndrome.
    • This malabsorption is more pronounced in DS compared to other intellectual disabilities.
    • The identified malabsorption is a likely contributor to vitamin and mineral deficiencies in DS.