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The Regulatory Role of Non-coding RNAs on Programmed Cell Death Four in Inflammation and Cancer

Mengxiang Zhao1, Nisha Zhu1, Fengyao Hao1

  • 1Central Laboratory Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Frontiers in Oncology
|October 18, 2019
PubMed

Insights

Noncoding RNAs (ncRNAs) regulate Programmed Cell Death 4 (PDCD4), a tumor suppressor. This review explores how ncRNAs impact PDCD4 expression and function in cancer and inflammatory diseases, offering insights for new treatments.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Programmed cell death 4 (PDCD4) is a crucial tumor suppressor involved in transcription, translation, and apoptosis.
  • While PDCD4's downstream effects are known, its upstream regulation, particularly by noncoding RNAs (ncRNAs), remains underexplored.
  • ncRNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), significantly influence the pathogenesis of various diseases.

Purpose of the Study:

  • To systematically review the pleiotropic regulation of PDCD4 by ncRNAs in cancer and inflammatory disorders.
  • To elucidate the mechanisms by which ncRNAs modulate PDCD4 expression and function.
  • To highlight the potential of targeting ncRNA-PDCD4 interactions for novel therapeutic strategies.

Main Methods:

  • Literature review of recent studies on ncRNA-PDCD4 interactions.
  • Analysis of ncRNA targeting mechanisms, including 3'-untranslated region (UTR) binding.
  • Synthesis of findings related to PDCD4 regulation in cancer and inflammatory conditions.

Main Results:

  • Numerous ncRNAs, such as miR-21, directly target PDCD4, influencing its expression and function.
  • ncRNAs can act as oncogenes or tumor suppressors by modulating PDCD4 levels.
  • Dysregulation of PDCD4 by ncRNAs is implicated in tumor proliferation, migration, and invasion.

Conclusions:

  • ncRNAs play a critical role in regulating PDCD4 in cancer and inflammatory diseases.
  • Understanding these ncRNA-PDCD4 interactions is key to developing targeted therapies.
  • This review provides a foundation for future research into ncRNA-based treatments for PDCD4-associated pathologies.
Keywords:
PDCD4cancerinflammationlncRNAmiRNA

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