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Related Experiment Video

Updated: Jan 5, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
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Zieve's Syndrome Presenting With Severe Hypertriglyceridemia.

Faiza Choudhry1, Jolian Kathawa1, Kelsey Kerton1

  • 1Department of Internal Medicine, Ascension Macomb-Oakland Hospital, Warren, MI.

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|October 18, 2019
PubMed
Summary

Zieve's syndrome (ZS), a rare condition linked to alcoholic steatohepatitis, typically presents with anemia, jaundice, and hyperlipidemia. This case highlights ZS with severe hypertriglyceridemia, necessitating plasmapheresis, a first in reported literature.

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Area of Science:

  • Hepatology
  • Hematology
  • Endocrinology

Background:

  • Zieve's syndrome (ZS) is a rare condition associated with alcoholic steatohepatitis.
  • It is characterized by hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia.

Observation:

  • This report details a Zieve's syndrome case with severe hypertriglyceridemia.
  • The patient's condition required plasmapheresis for management.

Findings:

  • This is the first reported case of Zieve's syndrome presenting with severe hypertriglyceridemia requiring plasmapheresis.
  • The case expands the clinical spectrum of Zieve's syndrome.

Implications:

  • This case underscores the importance of recognizing severe hypertriglyceridemia as a potential manifestation of Zieve's syndrome.
  • Early identification and intervention, including plasmapheresis, may be crucial for managing severe hypertriglyceridemia in ZS patients.
  • Further research into the mechanisms and management of hypertriglyceridemia in Zieve's syndrome is warranted.