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Updated: Jan 5, 2026

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study
Mohit Ganguly1,2, Jeremy B Ford1,2, Junqi Zhuo3
1Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.
Abstract:
Thermal block of unmyelinated axons may serve as a modality for control, suggesting a means for providing therapies for pain. Computational modeling predicted that potassium channels are necessary for mediating thermal block of propagating compound action potentials (CAPs) with infrared (IR) light. Our study tests that hypothesis. Results suggest that potassium channel blockers disrupt the ability of IR to block propagating CAPs in Aplysia californica nerves, whereas sodium channel blockers appear to have no significant effect. These observations validate the modeling results and suggest potential applications of thermal block to many other unmyelinated axons.
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